Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy―covering virtually all aspects of hematology in one definitive resource.

• Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology―in one convenient volume.
• Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.
• Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies
• Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.
• Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.
• Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.
• Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.
• Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.
• Presents relevant basic science as background for clinical application in later sections.

Contents

۱. Anatomy and Physiology of the Gene
۲. Epigenomics in Hematology
۳. Genomic Approaches to Hematology
۴. Regulation of Gene Expression in Hematology
۵. Genome Editing
۶. Signaling Transduction and Metabolomics
۷. Protein Architecture: Relationship of Form and Function
۸. Pharmacogenomics and Hematologic Diseases
۹. Hematopoietic Stem Cell Biology
۱۰. Mitochondria and Hematopoiesis
۱۱. Cytokines, Chemokines, Other Growth Factors, and Their Receptors
۱۲. Role of Chemokines in Leukocyte Trafficking
۱۳. Stem Cell Model of Hematologic Diseases
۱۴. Hematopoietic Microenvironment
۱۵. Cell Adhesion
۱۶. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment
۱۷. Control of Cell Division
۱۸. Cell Death
۱۹. Aging and Hematopoiesis
۲۰. Dendritic Cell Biology
۲۱. Natural Killer Cell Immunity AND THERAPY
۲۲. B-Cell Development
۲۳. Complement And Immunoglobulin Biology Leading To Clinical Translation
۲۴. T-Cell Immunity
۲۵. Unmodified Ex Vivo Expanded T Cells
۲۶. Treatment of Hematologic Malignancies With Genetically Modified T Cells
۲۷. Biology Of Erythropoiesis, Erythroid Differentiation, And Maturation
۲۸. Granulocytopoiesis and Monocytopoiesis
۲۹. Thrombocytopoiesis
۳۰. Inherited Bone Marrow Failure Syndromes

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