Patients with Parkinson’s disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson’s disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson’s Disease, which are poorly recognized and inadequately treated by clinicians.

The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future.

Edited by members of the UK Parkinson’s Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson’s disease and points the way towards future research.

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Contents

۱ What are the non-motor symptoms; of Parkinson’s disease?
۲ Non-motor symptoms and pre-motor diagnosis of Parkinson’s disease
۳ Non-motor symptoms in the early motor stages of Parkinson’s disease
۴ Non-motor symptoms in advanced Parkinson’s disease
۵ Assessment tools for non-motor symptoms of Parkinson’s disease in the clinical setting
۶ Imaging non-motor aspects of Parkinson’s disease
۷ Non-motor signs in genetic forms of Parkinson’s disease
۸ Cognitive dysfunction in Parkinson’s disease
۹ Depression anxiety and apathy in Parkinson’s disease
۱۰ Dementia in Parkinson’s disease
۱۱ Fatigue in Parkinson’s disease
۱۲ Psychosis in Parkinson’s disease
۱۳ Neurobiology of sleep: the role of dopamine in Parkinson’s disease-related sleep disorders
۱۴ Rapid eye movement sleep behaviour disorder in Parkinson’s disease
۱۵ Parkinson’s disease and restless legs syndrome
۱۶ Excessive daytime sleepiness in Parkinson’s disease
۱۷ Bladder dysfunction in Parkinson’s disease
۱۸ Sexuality in Parkinson’s disease
۱۹ Gastrointestinal dysfunctions in Parkinson’s disease
۲۰ Postural hypotension in Parkinson’s disease
۲۱ Sialorrhoea in Parkinson’s disease
۲۲ Olfaction in Parkinson’s disease
۲۳ Chronic pain and Parkinson’s disease
۲۴ Visual function in Parkinson’s disease
۲۵ Non-motor symptoms and health-related quality of life: an overview
۲۶ Non-motor symptoms and co-morbidity in Parkinson’s disease
۲۷ Non-motor symptoms of Parkinson’s disease and the effects of deep brain stimulation surgery
۲۸ Impulse dyscontrol and dopamine dysregulation syndrome
۲۹ Treatment-related non-motor symptoms in Parkinson’s disease
۳۰ Thermoregulatory dysfunction in Parkinson’s disease
۳۱ The role of continuous dopaminergic stimulation in the management of non-motor symptoms in Parkinson’s disease