Orthopaedic Basic Science: Foundations of Clinical Practice fifth edition is your concise and clinically relevant resource for the scientific basis of orthopaedic surgery in support of the diagnosis and treatment of musculoskeletal diseases and conditions.

Reach for this title to explain the functions, advancements, and limitations of the science behind the decisions, treatments, and procedures you perform in your practice every day. Use it to build and reinforce your foundation of knowledge for applying advances in scientific discovery to your decision making in the clinic and the OR.

Orthopaedic Basic Science new edition is completely rewritten, reorganized, and refocused through a collaboration of senior scientists and clinicians with new chapters and content reflecting the many advancement in and around the science behind musculoskeletal medicine, including epigenetics, biomaterials, tissue engineering, gender differences, and metabolic bone disease, as well as the growth of registries and best-practice guidelines.

Sections include:

• Basic Disciplines in Orthopaedic Surgery
• Structure and Function of Musculoskeletal Tissues
• Pathophysiology and Orthopaedic Medicine
• Repair and Regeneration
• Principles of Clinical Information

Contents

۱ Genetics, Gene Expression, and Epigenetics
۲ Cell Biology, Cell Differentiation, and Stem Cells of the Skeletal System
۳ Biology and Mechanics of the Skeletal Extracellular Matrix
۴ Biomechanics of the Skeletal System
۵ Gait and Gait Disturbances
۶ Biomaterials in Orthopaedic Practice
۷ The Biologic Response to Orthopaedic Implants
۸ Osteolysis and Implant Loosening
۹ The Development, Growth, and Morphogenesis of the Skeleton
۱۰ Biology of Bone
۱۱ Bone Biomechanics
۱۲ Biology of Articular Cartilage
۱۳ Biomechanics of Articular Cartilage and Its Response to Loading
۱۴ Meniscus and Labrum
۱۵ Synovium and Joint Biology
۱۶ Joint Cross—talk Among Bone, Synovium, and Articular Cartilage
۱۷ The Intervertebral Disk
۱۸ Tendons and Ligaments
۱۹ Form and Function of Skeletal Muscle
۲۰ Structure and Physiology of Peripheral Nerves
۲۱ Venous Thromboembolic Disease and Fat Embolism Syndrome
۲۲ Biology and Diagnosis of Skeletal Infection
۲۳ Treatment of Skeletal Infections
۲۴ Sex and Gender Differences in Clinical and Preclinical Studies
۲۵ Metabolic Bone Diseases
۲۶ Rare Genetic Bone Diseases of Orthopaedic Significance
۲۷ Osteonecrosis
۲۸ Osteoarthritis
۲۹ Neuromuscular Diseases
۳۰ Lumbar Spondylosis, Degenerative Disk Disease, and Radiculopathy
۳۱ Fracture Repair
۳۲ Contemporary Concepts in Soft—Tissue Wound Management
۳۳ Articular Cartilage Repair: Augmentation, Regeneration, Replacement, and Substitution
۳۴ Tendon and Ligament Healing
۳۵ Skeletal Muscle Repair and Regeneration
۳۶ Diagnosis and Repair of Peripheral Nerve Injuries
۳۷ Cells and Materials for Soft-Tissue Repair and Regeneration
۳۸ Ethics of Clinical Practice in Orthopaedic Surgery
۳۹ Ethical Principles of Clinical Research
۴۰ Principles of Clinical Studies
۴۱ Observational Studies
۴۲ Randomized Controlled Trials
۴۳ Systematic Reviews and Meta—Analysis
۴۴ Evidence—Based Medicine and Best-Practice Guidelines
۴۵ Role of Cohort Studies and Registries in Musculoskeletal Healthcare and Research
۴۶ Fundamentals of Cost-Effectiveness Research
۴۷ The Product Development Process From Discovery, Through the FDA, and Into the Clinic