Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. In psoriasis, lesions skin cells, keratinocytes, grow too quickly, resulting in thick, white, silvery or red patches on skin. Normal skin cells grow gradually and flake off about every four weeks, but psoriasis causes new skin cells to move rapidly to the surface of the skin in days rather than weeks. Psoriasis symptoms often appear on the elbows, scalp, feet, knees, hands, or lower back, or as flaking or patches on the skin. It is most common in adults, but teenagers and children can also suffer from psoriasis.

Psoriasis is not only a skin condition; it is a chronic disease of the immune system. Chronic psoriasis is associated with other health conditions such as psoriatic arthritis, several inflammatory disorders, type 2 diabetes, and cardiovascular disease. This book provides extensive coverage of psoriasis and psoriatic arthritis. It features information on epidemiology and etiology of psoriasis, pathogenesis, genetics of psoriasis, clinical manifestations, and treatment options using cutting-edge drugs including adalimumab and tofacitinib.

Natural phytochemicals and nutraceuticals have demonstrated efficacy in ameliorating psoriasis. The book dedicates comprehensive coverage of nutraceutical therapeutic options including antioxidants, bioactive peptides, carotenoids, alpha lipoic acid, curcumin, and whey protein. These inexpensive natural therapeutics are not associated with any known adverse side effects.

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Contents

Chapter 1: Epidemiology of Psoriasis and Psoriatic Arthritis
Chapter 2: Genetics of Psoriasis and Psoriatic Arthritis
Chapter 3: Inflammation in Psoriasis and Psoriatic Arthritis
Chapter 4: Psoriasis and Diabetes: An Unholy Alliance
Chapter 5: Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease
Chapter 6: Multifaceted Role of Thl7 Cells in Psoriatic Disease
Chapter 7: Nerve Growth Factor and Its Receptor System in Rheumatologic Diseases and Pain Management
Chapter 8: Psoriasis: Clinical Spectrum
Chapter 9: Clinical Spectrum of Spondyloarthritis
Chapter 10: Comorbidities in Psoriatic Arthritis
Chapter 11: Current Recommendations for the Treatment of Psoriasis
Chapter 12: Management of Psoriatic Arthritis
Chapter 13: Targeting IL-23/IL-17 Axis for Treatment of Psoriasis and Psoriatic Arthritis
Chapter 14: DMARD Treatment in Patients with Psoriatic Arthritis
Chapter 15: Topical Therapies for Psoriasis
Chapter 16: Overview of JAK-STAT Pathways in Spondyloarthritis
Chapter 17: Concept of Total Care
Chapter 18: Nutraceutical Components in the Treatment of Psoriasis and Psoriatic Arthritis
Chapter 19: Herbal Products for the Treatment of Psoriasis
Chapter 20: Impact of Nutrition and Dietary Supplementation on Psoriasis Pathology