Updated by a team of internationally renowned experts, this book gives a thorough overview of fetal pathophysiology and an evidence base for in utero: both medical (non-invasive) and surgical treatments. Many topics are expanded to cover recent advances, including: stem cell transplantation; tissue scaffolding; minimally invasive approaches to ‘open fetal surgery’; the etiology, prevention and treatment of preterm birth and PROM; the genetic etiologies of fetal disease; and gene therapy. In addition, there are in-depth discussions as to the role of open fetal myelomeningocele repair and several fetoscopic approaches to therapy. The international editors have added important new chapters on reducing stillbirth and prenatal counselling. This book is an invaluable reference guide to the latest fetal therapy options, and an essential, in-depth study book for maternal-fetal and neonatology specialists.

Book Description

About the Author

Contents

۱ The Rationale for Fetal Therapy
۲ A Fetal Origin of Adult Disease
۳ Human Embryology: Molecular Mechanisms of Embryonic Disease
۴ Human Genetics and Fetal Disease: Assessment of the Fetal Genome
۵ Interventions in Pregnancy to Reduce Risk of Stillbirth
۶ Fetal Therapy Choices: Uncertain and Emotional Decisions and the Doctor’s Role in Parental Decision-Making
۷ The Ethics of Consent for Fetal Therapy
۸ Open Fetal Surgery: Is There Still a Role?
۹ The Artificial Womb
۱۰ Management of Red Cell Alloimmunization
۱۱ Fetal and Neonatal Alloimmune Thrombocytopenia: Clinical Disease and Management
۱۲ Structural Heart Disease: Embryology
۱۳ Structural Heart Disease: Genetic Influences
۱۴ Deciphering the Mechanisms of Developmental Heart Disease: Research from Embryonic Knockout Mice
۱۵ In Utero Intervention for Cardiac Disease
۱۶ Fetal Cerebral Consequences of Structural Heart Disease: Can These Be Ameliorated?
۱۷ Fetal Supraventricular Tachyarrhythmias: Pharmacokineticsr Modes of Action, and Results of Anti-Arrhythmic Drug Therapy
۱۸ Fetal Dysrhythmias: Diagnosis and Clinical Management
۱۹ Manipulation of Amniotic Fluid Volume: Homeostasis of Fluid Volumes in the Amniotic Cavity
۲۰ Oligohydramnios and Polyhydramnios: Therapeutic Manipulation of Amniotic Fluid Volume
۲۱ Fetal Infections: Immune Response to Infections during Fetal Life
۲۲ Fetal Infections: Clinical Management
۲۳ Fetal Growth Restriction: Placental Basis and Implications for Clinical Practice
۲۴ Fetal Growth Restriction: Diagnosis and Management
۲۵ Screening and Intervention for Fetal Gro.’vth Restriction
۲۶ Maternal and Fetal Therapy: Can We Optimize Fetal Growth?
۲۷ The Pathogenesis of Preterm Birth: A Guide to Potential Therapeutic Targets
۲۸ Clinical Interventions for the Prevention and Management of Spontaneous Preterm Birth in the Singleton Fetus
۲۹ Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies
۳۰ Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to Delivery
۳۱ Twin-to-Twin Transfusion Syndrome: Placental and Fetal Pathogenesis
۳۲ Twin-to-Twin Transfusion Syndrome: Treatment by Fetoscopic Laser Coagulation of the Placental Vascular Anastomoses on the Chorionic Plate
۳۳ Interventions for Early and Late Twin-Twin Transfusion Syndrome
۳۴ Diagnosis and Treatment in Twin Anemia Polycythemia Sequence
۳۵ Neurological and Long-Term Neurodevelopmental Outcome after Fetal Therapy in Complicated Monochorionic Twins
۳۶ The Diagnosis and Detection of Fetal Growth Restriction in Monochorionic Twin Pregnancies
۳۷ Clinical Outcome and Management of Selective Fetal Growth Restriction in Monochorionic Twins
۳۸ Twin Reversed Arterial Perfusion Sequence: Pathophysiology and In Utero Treatment
۳۹ Fetal Reduction and Selective Termination
۴۰ Selective Termination of One Fetus in Monochorionic Twin Pregnancies
۴۱ Lower Urinary Tract Obstruction: Pathophysiology,Prenatal Assessment and In Utero Intervention
۴۲ Fetal Pleural Effusions and Pulmonary Pathology: Pathophysiology and Clinical Management
۴۳ Neural Tube Anomalies: An Update on the Pathophysiology and Prevention
۴۴ Neural Tube Anomalies: Clinical Management by Open Fetal Surgery
۴۵ Open Neural Tube Defect Repair: Development and Refinement of a Fetoscopic Technique
۴۶ Fetal Tumors: Clinical Management
۴۷ Congenital Diaphragmatic Hernia: Pathophysiology and Antenatal Assessment
۴۸ Congenital Diaphragmatic Hernia: In Utero Treatment Today and Tomorrow
۴۹ Stem Cell Transplantation: Clinical Potential in Treating Fetal Genetic Disease
۵۰ Strategies to Repair Defects in the Fetal Membrane
۵۱ Tissue Engineering and the Fetus
۵۲ Gene Therapy: Principles and Clinical Potential
۵۳ Fetal Therapy and Translational Studies: Global Alignment Coordination and Collaboration in Perinatal Research
۵۴ Congenital Anomaly Registers: The European Experience
۵۵ A Challenge for Prenatal Diagnosis in Developing Countries: Zika Virus as an Exemplar