Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs.

NEW to the Sixth Edition…

• A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives.
• Full color throughout
• A companion website that offers full text online and an image bank.
• A new introductory section of chapters on basic sciences as related to the field
• Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women’s health issues, cancer, sickle cell disease, and other groups.
• Overview chapters preceding each section address broad topics of general importance.

Contents

Chapter 1.  History of the Field
Chapter 2.  Molecular Evolution of the Vertebrate Blood Coagulation System
Chapter 3.  Molecular and Clinical Genetics
Chapter 4:  Coagulation Enzymology
Chapter 5: Cell Biology, Protein Processing, and Cell Signaling
Chapter 6: Cellular and Molecular Immunology
Chapter 7:  Biostatistics and Epidemiology: The Basic Science of Clinical Research
Chapter 8: Overview of Basic Coagulation and Fibrinolysis
Chapter 9:  The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression
Chapter 10: Genetics of Coagulation Proteins
Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation
Chapter 12: Factors V and VIII
Chapter 13: Structure and Function of von Willebrand Factor
Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins
Chapter 15A:  Factor XI
Chapter 15B: The Factor XII-driven Plasma Contact System
Chapter 16:  Fibrinogen Structure and Function
Chapter 17: Factor XIII
Chapter 18: Antithrombin and the Serpin Family
Chapter 19:  Protein C and S and Thrombomodulin System
Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis
Chapter 21:  Inhibitors of Fibrinolysis
Chapter 22: Overview of Platelet Structure and Function
Chapter 23:  Platelet Production: Cellular and Molecular Regulation
Chapter 24: Megakaryocyte Structure and Platelet Biogenesis
Chapter 25:  Thrombopoietin

More…

Chapter 128: Multtrauma Derangements in Hemostasis and Thrombosis
Chapter 129: Blood Management in the Cardiovascular Surgery Patient
Chapter 130: Thrombo-Hemorrhagic Events in the Elderly