Epilepsy is a prevalent and serious neurological disorder. This vital textbook addresses the role of neuroimaging as a unique tool to provide in vivo biomarkers aimed at furthering our understanding of causes and consequences of epilepsy in a day-to-day clinical context. Unique in its approach, this translational book presents a critical appraisal of advanced pre-clinical biomarkers that allows capturing epileptogenesis at molecular, cellular, and neuronal system levels. The book is divided into four sections. Part I includes a series of chapters focused on imaging of early disease stages. Part II discusses lesion detection and network analysis methods. Part III focuses on imaging methods used to predict response to antiepileptic drugs and surgery. Finally, Part IV presents imaging techniques used to evaluate disease consequence.

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Contents

Chapter 1 Imaging Biomarkers for Febrile Status Epilepticus and Other Forms of Convulsive Status Epilepticus
Chapter 2 Experimental MRI Approaches to Study Posttraumatic Epilepsy
Chapter 3 Imaging Biomarkers of Acquired Epilepsies
Chapter 4 Imaging and Cognition in Children with New-Onset Epilepsies
Chapter 5 Imaging Genetics for Benign Mesial Temporal Lobe Epilepsy
Chapter 6 Computational Neuroimaging of Epilepsy
Chapter 7 Imaging White Matter Pathology in Epilepsy
Chapter 8 Network Modeling of Epilepsy Using Structural and Functional MRI
Chapter 9 Mapping Metabolism and Inflammation in Epilepsy
Chapter 10 Interictal and Ictal Brain Network Changes in Focal Epilepsy
Chapter 11 Ictal Events Imaged through SPECT
Chapter 12 Imaging Cortical and Subcortical Circuitry in Generalized Epilepsies
Chapter 13 Prevention of Epileptogenesis in Animal Models
Chapter 14 Imaging Mechanisms of Drug Resistance in Experimental Models of Epilepsy
Chapter 15 Biomarkers of Drug Response and Pharmacoresistance to Epilepsy
Chapter 16 Predicting the Outcome of Surgical Interventions for Epilepsy Using Imaging Biomarkers
Chapter 17 Imaging Neural Excitability and Networks in Genetic Absence Epilepsy Models
Chapter 18 Network Excitability and Cognition in the Developing Brain
Chapter 19 Imaging Comorbidities in Epilepsy: Depression
Chapter 20 Tracking Epilepsy Disease Progression with Neuroimaging
Chapter 21 Imaging Biomarkers to Study Cognition in Epilepsy