Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient.

Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer’s disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens.

The book’s editor, Susan A. Masino, brings her unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this one of a kind book, section editors Eric Kossoff, Jong Rho, Detlev Boison, and Dominic P. D’Agostino lend their oversight on their respective sections.

About the Author

Contents

۱. Overview: Ketogenic Diets and Pediatric Epilepsy: An Update
۲. ”Alternative” Ketogenic Diets
۳. Dietary Therapy in Adults: Historyr Demand, and Results
۴. How Do You Implement the Diet?
۵. Glutl Deficiency and the Ketogenic Diets
۶. Ketogenic Diet in Established Epilepsy Indications
۷. Ketogenic Diet for Other Epilepsies
۸. The Ketogenic Diet and Related Therapies in “Mover Situations: Idiopathic Generalized Epilepsy Syndromes
۹. Ketogenic Diet in Status Epilepticus
۱۰. Preventing Side Effects and Diet Discontinuation
۱۱. Overview: Expanded Uses of Ketogenic Therapies
۱۲. Metabolism-Based Treatments to Counter Cancer: Scientific Rationale
۱۳. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer
۱۴. Metabolic Therapy for Autism Spectrum Disorder and Comorbidities
۱۵. Glucose and Ketone Metabolism in the Aging Brain: Implications for Therapeutic Strategies to Delay the Progression of Alzheimer’s Disease
۱۶. Ketogenic Diet and Ketones for the Treatment of Traumatic Brain and Spinal Cord Injury
۱۷. Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New Indications
۱۸. Dietary Therapy for Neurological Disorders: Focus on Amyotrophic Lateral Sclerosis,. Parkinson’s Diseaser Mood Disorders, and Migraine
۱۹. Overview of Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms
۲۰. Ketogenic Diet and PPARgamma
۲۱. Ketogenic Diet in a Hippocampal Slice: Models and Mechanisms
۲۲. Metabolic Therapy and Pain
۲۳. Ketogenic Diet, Adenosine, Epigenetics, and Antiepileptogenesis
۲۴. Ketogenic Diet, Aging, and Neurodegeneration
۲۵. Endocrine and Reproductive Effects of Ketogenic Diets
۲۶. Alzheimer’s Disease: Causes and Treatment
۲۷. Mitigation of Damage from Reactive Oxygen Species and Ionizing Radiation by Ketone Body Esters
۲۸. Metabolic Seizure Resistance via BAD and KATP Channels
۲۹. Lactate Dehydrogenase: A Novel Metabolic Target
۳۰. Effects of the Ketogenic Diet on the Blood-Brain Barrier
۳۱. Overview of Ketone-Based Metabolism: General Health and Metabolic Alternatives
۳۲. Ketone Supplementation for Health and Disease
۳۳. Identifying the Molecular Mechanism of the Medium Chain Triglyceride (Ketogenic) Diet
۳۴. Triheptanoin in Epilepsy and Beyond
۳۵. Amino Acids in the Treatment of Neurological Disorders
۳۶. ۲-Deoxyglucose: Metabolic Control of Seizures through Inhibition of Glycolysis
۳۷. Ketogenic Diets as Highly Effective Treatments for Diabetes Mellitus and Obesity
۳۸. Keto-Adaptation in Health and Fitness
۳۹. Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation and Matthew’s Friends