Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.

Human skin is the most voluminous connective tissue and the most abundant type of tissue in the human body. Human skin, like all other organs, undergoes natural aging as a consequence of the passage of time. In addition, human skin, unlike other organs, continuously experience harmful stress and damage from environmental sources such as solar UV irradiation.

Features

• Describes the molecular mechanisms of human skin-aging and age-related skin diseases
• Emphasizes both laboratory and clinical research in human skin-aging
• Provides insight into current information regarding development of mechanism-based anti-skin-aging products

Contents

Chapter 1: Molecular Mechanisms of Human Skin Connective Tissue Aging
Chapter 2: (Myo)fibroblasts/Extracellular Matrix in Skin Wound and Aging
Chapter 3: Changes of Skin Barrier with Aging
Chapter 4: Skin Dryness is a Factor that Accelerates Collagen Degradation and Results in Wrinkling
Chapter 5: CCN Family Proteins in Skin Connective Tissue Aging
Chapter 6: Fibroblasts as Drivers of Healing and Cancer Progression: From In vitro Experiments to Clinics
Chapter 7: Mitochondrial DNA Common Deletion in Human Skin Connective Tissue Aging
Chapter 8: Nanodermatology: Nanoscale Therapeutics for Topical Application
Chapter 9: Skin Conditions in Elderly
Chapter 10: Regenerative Properties of Laser Light
Chapter 11: Aging Skin: A Window to the Body
Chapter 12: Skin Aging with a Focus on the Cornified Envelope