Now in its 4e, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine.

• Recognizes the critical importance of the Wnt signaling pathway for bone health
• Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone
• Examines essential updates on estrogen prevention and treatment and the recent results from the WHO
• Discusses the controversial topics of screening and clinical trial design for drug registration
• Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone
• Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics

Review

Praise for Previous Edition:
“…Osteoporosis is quite comprehensive; indeed, topics that typically receive brief treatment elsewhere (osteoporosis in minority groups and in men) receive entire chapters here…”–THE NEW ENGLAND JOURNAL OF MEDICINE

From the Back Cover

“Osteoporosis has become the standard text for persons interested in the pathophysiology and management of metabolic bone diseases. It covers all aspects of these issues and the authors represent the leading experts in these areas. It is a must read for the clinician, researcher and student!”

—B. Lawrence Riggs, MD, Professor of Medicine Emeritus, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

“All aspects of osteoporosis from bone biology to treatment of your patients are concisely summarized in the fourth edition ofOsteoporosis . Not only will you find updates to the topics covered in previous editions but also the addition of new knowledge areas and controversies that have arisen in the field. The editors included contributions from over one hundred osteoporosis experts. This comprehensive book is the best resource for anyone interested in bone health and those taking care of patients with osteoporosis. Add this valuable reference on osteoporosis to your bookshelf!”

–Diane L. Schneider, MD, MSc, Author, The Complete Book of Bone Health; Cofounder,۴BoneHealth.org; Consultant, University of California, San Diego, California, USA

Praise for the Previous Editions

“…interesting, comprehensive and up-to-date: each chapter has something new and important to say…”–JOURNAL OF BONE AND JOINT SURGERY“A series of strong chapters written by experts in the field covers bone biology& this is a reference work that should be useful for basic scientists in the bone field as well as for rheumatologists, endocrinologists, and other clinicians who can benefit from the resources put together so ably by this group of editors and authors.”-THE NEW ENGLAND JOURNAL OF MEDICINE

Contents

Introduction
The Bone Organ System: Form and Function
The Nature of Osteoporosis
The Economics of Osteoporosis
Reflections on Osteoporosis
Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the
Understanding of Osteoporosis
Basic Science/Bone Biology
Osteoblast Biology
Osteoclast Biology
Osteocytes
The Regulatory Role of Matrix Proteins in Mineralization of Bone
Development of the Skeleton
Mouse Genetics as a Tool to Study Bone Development and Physiology
Parathyroid Hormone and Parathyroid Hormone-Related Protein
Vitamin D: Biology, Action, and Clinical Implications
Regulation of Bone Cell Function by Estrogens
Androgens and Skeletal Biology: Basic Mechanisms
Phosphatonins
Wnt Signaling in Bone
Cytokines and Bone Remodeling
Skeletal Growth Factors
Intercellular Communication During Bone Remodeling
Structural and Biomechanics
Skeletal Development: Mechanical Consequences of Growth, Aging and Disease
Inhibition of Osteoporosis by Biophysical Intervention
Biomechanics of Age-Related Fractures
Bone Quality
Epidemiology & Risk Factors
Epidemiologic Methods in Studies of Osteoporosis
Race, Ethnicity and Osteoporosis
The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions
Bone Mineral Acquisition in Utero and During Infancy and Childhood
Bone Acquisition in Adolescence
Genetic Determinants of Osteoporosis
Nutrition and Risk for Osteoporosis
Physical Activity in Prev