Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years.

Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required.

This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing.

• Comprehensive information on drug mechanisms, basic physiology and biochemistry, and underlying pathophysiology of disease – suitable for students from many disciplines
• Clear figures to aid understanding, including data figures as well as mechanistic diagrams,
• Key points box summaries, clinical boxes and colour-coded chapters help to master difficult concepts
• Emphasis on therapeutic drugs to help apply theory to practice
• Over 150 questions and 12 clinical cases to test your knowledge
• An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customise your content, make notes and highlights, and have content read aloud
• New chapters on drugs and the eye and the pharmacological management of headache
• Revised information on biopharmaceuticals (including RNA drugs), antivirals (including Covid-19 therapies) as well as general principles of antimicrobial therapy.
• A completely revised and updated chapter on lifestyle drugs
• Recent advances in oxygen sensing and response to reduced oxygen tension
• Expanded chapters on dementia and analgesic drugs

Review

Award-winning textbook on pharmacology for students

Contents

۱. What is pharmacology?
۲. How drugs act : general principles
۳. How drugs act : molecular aspects
۴. How drugs act : cellular aspects – excitation, contraction and secretion
۵. How drugs act : biopharmaceuticals and gene therapy
۶. Cell proliferation, apoptosis, repair and regeneration
۷. Cellular mechanisms : host defence
۸. Method and measurement in pharmacology
۹. Absorption and distribution of drugs
۱۰. Drug metabolism and elimination
۱۱. Pharmacokinetics
۱۲. Individual variation, pharmacogenomics and personalised medicine
۱۳. Chemical mediators and the autonomic nervous system
۱۴. Cholinergic transmission
۱۵. Noradrenergic transmission
۱۶. ۵-Hydroxytryptamine and the purines
۱۷. Local hormones: histamine, lipids, peptides and proteins
۱۸. Cannabinoids
۱۹. Nitric oxide and related mediators
۲۰. The heart
۲۱. The vascular system
۲۲. Atherosclerosis and lipoprotein metabolism
۲۳. Haemostasis and thrombosis
۲۴. Haematopoietic system and treatment of anaemia
۲۵. Anti-inflammatory and immunosuppressant drugs
۲۶. Skin
۲۷. The eye
۲۸. Respiratory system
۲۹. The kidney and urinary system
۳۰. The gastrointestinal tract
۳۱. The control of blood glucose and drug treatment of diabetes mellitus
۳۲. Obesity
۳۳. The pituitary and the adrenal cortex
۳۴. The thyroid
۳۵. The reproductive system
۳۶. Bone metabolism
۳۷. Chemical transmission and drug action in the central nervous system
۳۸. Amino acid transmitters
۳۹. Other transmitters and modulators
۴۰. Neurodegenerative diseases
۴۱. General anaesthetic agents
۴۲. Headache
۴۳. Analgesic drugs
۴۴. Local anaesthetics and other drugs affecting sodium channels
۴۵. Anxiolytic and hypnotic drugs
۴۶. Antiepileptic drugs
۴۷. Antipsychotic drugs
۴۸. Antidepressant drugs
۴۹. Psychoactive drugs
۵۰. Drug use and addiction
۵۱. Basic principles of antimicrobial chemotherapy
۵۲. Antibacterial drugs
۵۳. Antiviral drugs
۵۴. Antifungal drugs
۵۵. Antiprotozoal drugs
۵۶. Antihelminthic drugs
۵۷. Anticancer drugs
۵۸. Harmful effects of drugs
۵۹. Lifestyle and drugs in sport
۶۰. Drug discovery and development