Nanoneuroscience, nanoneurosurgery, and nanobioelectronics have the potential to revolutionize medicine and improve the prevention, diagnosis, and treatment of neurological disorders over the next 10-20 years. The Textbook of Nanoneuroscience and Nanoneurosurgery presents a state-of-the-art review of the field, providing current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience, and neuroradiology.

The text also reviews the latest regulatory guidelines that influence the translation of nanotechnological research from the laboratory to the clinic, as well as the most recent information on biodevices and pharmaceutical spinoffs. It highlights presidential and congressional initiatives and programs that may significantly impact the field in the near future. Chapters discuss the latest science and technologies―which are applied to diagnosis and treatment of neurological disorders―as well as regulatory issues that impact product development.

This volume describes advances that have already been translated to the clinic or hold significant promise for future application in nanoneurosurgery, as well as their potential impact. A full-color text, the book contains contributions by more than 120 researchers, original and descriptive illustrations, and more than 3,000 references. Offering broad coverage of nanotechnological applications in diverse areas and addressing FDA regulation and healthcare policy, this volume provides a foundation of ideas and methods for scientists and physicians to devise successful, less invasive procedures for future treatment of nervous system disorders.

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Contents

Chapter 1 – From Nanotechnology to Nanoneuroscience/Nanoneurosurgery and Nanobioelectronics: A Historical Review of Milestones
Chapter 2 – Nanoneurology and Nanoneurosurgery
Chapter 3 – Nanopolymers and Nanoconjugates for Central Nervous System Diagnostics and Therapies
Chapter 4 – Micelles and Liposomes: Lipid Nanovehicles for Intracerebral Drug Delivery
Chapter 5 – Peptide and Protein-Based Nanoparticles
Chapter 6 – Endohedral Metallofullerenes, Iron Oxide Agents, and Gold Nanoparticles for Brain Imaging
Chapter 7 – Carbon Nanoplatforms and Their Application for Neurological Disorders
Chapter 8 – Dendrimers
Chapter 9 – Ligand-Based Targeting of Therapeutic and Imaging Agents for Cancer
Chapter 10 – Immune-Based Targeting in Cancer
Chapter 11 – Directed Drug Convection Using Magnetic Nanoparticles as Therapeutic Carriers: Meeting the Challenge of Specific Brain Pharmacotherapeutics, Non-Ligand-Based Central Nervous System Targeting, Including Magnetic Focusing
Chapter 12 – Intralesional and IntraparenchymaI Convection-Enhanced Delivery of Nanoparticles
Chapter 13 – Transport of Nanoparticles across Blood-Brain Barrier
Chapter 14 – Nanomedicine Treatment Strategies That Exploit Unique Characteristics of Tumor Vasculature and Microenvironment
Chapter 15 – Focused Ultrasound for Noninvasive Neuromodulation
Chapter 16 – Nanosensors
Chapter 17 – Implantable Infusion Pumps Incorporating Nanotechnology
Chapter 18 – Nanostructured Surfaces for Intracerebral Neurotransmitter Recording
Chapter 19 – Therapy for Neuronopathic Lysosomal Storage Diseases
Chapter 20 – Nanotechnology for Cerebral Aneurysm Treatment
Chapter 21 – Improving Treatment of Stroke through Nanotechnology
Chapter 22 – Molecular Medical Devices for Nanoneurosurgery
Chapter 23 – Applications of Nanotechnology in Epilepsy
Chapter 24 – Applications of Nanotechnology to Diseases of the Spine
Chapter 25 – Nanoparticle-Based Treatment and Imaging of Brain Tumors: Potentials and Limitations
Chapter 26 – Tumor-Targeted Nanodrugs for Treatment of Primary Brain Tumors
Chapter 27 – Application of Nanotechnology in the Diagnosis and Treatment of Brain Metastasis
Chapter 28 – Nanotechnology in Extra-Axial and Pituitary Tumors
Chapter 29 – Using Nanoparticles in Diagnosis and Treatment of CNS Infection
Chapter 30 – Applications of Nanotechnology in Movement Disorders
Chapter 31 – Nanomedicine in Demyelinating Disease: Application to Diagnosis and Therapy in Multiple Sclerosis
Chapter 32 – Applications of Nanotechnology in Degenerative Disorders of the Brain
Chapter 33 – Brain-Machine Interface and Rehabilitation
Chapter 34 – Nanobioelectronics for Noninvasive Neuronal Therapy
Chapter 35 – In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanopaiticles
Chapter 36 – Nanorobotics for Neurosurgery
Chapter 37 – Imaging and Tracking Therapeutic Cells with Nanoparticles
Chapter 38 – Micro- and Nanotechnology in Nerve Repair
Chapter 39 – Nanotechnology: Applications to Pediatric Neurosurgery
Chapter 40 – Food and Drug Administration Regulatory Framework for Nanodrugs and Nanodevices and the Combination
Chapter 41 – Nanoneuroscience and Nanoneurosurgery: A Key Component of President Obama’s Brain Mapping Initiative